Multiple Choice Questions - Paper 1
Instructions for candidates
The examination consists of 30 multiple choice questions, each
divided into 5 different parts. Each part contains a statement
which could be true or false. Each question will have at least
one part which is true. For each part, you should indicate
whether you think it is true (T), false (F), or don’t know (DN).
You must fill in the relevant square with a black pen. One mark
will be given for each correct answer and one mark deducted for
each incorrect answer. You will not be marked for those questions
for which you have indicated "don’t know".
| 1. Viruses |
| Contain both DNA and RNA |
| May have an envelope |
| Have their own metabolism |
| May contain enzymes for replication |
| Cell wall |
| 2. The following are DNA viruses |
| Herpesviruses |
| Orthomyxoviruses |
| Enteroviruses |
| Hepadnaviruses |
| Parvoviruses |
| 3. The following are RNA viruses |
| Picornaviruses |
| Adenoviruses |
| Papillomaviruses |
| Rhabdoviruses |
| Rotaviruses |
| 4. Live attenuated vaccines are available against the following viruses |
| Influenza A Virus |
| Hepatitis B Virus |
| Rubella Virus |
| Yellow Fever Virus |
| Varicella-Zoster Virus |
| 5. The following antiviral agents is active against the following virus |
| Lamivudine and HIV |
| Lamivudine and HBV |
| Amantidine and Influenza B virus |
| Ribavirin and RSV |
| Acyclovir and HSV |
| 6. Herpes Simplex Encephalitis |
| Commonly affect the temporal lobe |
| Is usually diagnosed by culture of the CSF |
| May be diagnosed by PCR of the CSF |
| Should be treated with IV ganciclovir |
| May be diagnosed by the finding of specific antibody in the CSF |
| Causes a maculopapular rash |
| Respond to AZT therapy |
| Remains latent in sensory ganglia following primary infection |
| Recurrent episodes of Shingles usually occur |
| Patients with shingles are not infectious |
| 8. Cytomegalovirus (CMV) |
| Primary infection is usually symptomatic |
| An infectious mononucleosis-like syndrome may occur during primary infection. |
| May cause severe infection in immunocompromised individuals |
| Is teratogenic |
| Causes Kawasaki's Disease |
| 9. Epstein-Barr Virus (EBV) is associated with |
| Infectious Mononucleosis |
| Hepatitis |
| Burkitt's lymphoma |
| Nasopharyngeal carcinoma |
| Oral leukoplakia |
| Fifth disease |
| Roseala Infantum |
| Kaposi's Sarcoma |
| Infectious Mononucleosis-like illness |
| Oral leukoplakia |
| Are associated with genital cancers |
| May cause gastroenteritis |
| May cause conjunctivitis |
| May cause pneumonia |
| May cause warts |
| 12. Papillomaviruses |
| HPV-6 and HPV-11 are associated with genital cancers |
| HPV-16 and HPV-18 are associated with genital cancers |
| Warts caused by papillomaviruses may respond to interferon therapy |
| Papillomavirus infection is commonly diagnosed by viral culture |
| Are associated with progressive multifocal leucoencephalopathy (PML) |
| 13. Coxsackie B Virus is associated with the following |
| Paralytic illness |
| Myocarditis |
| Bornholm's disease |
| Severe congenital infection |
| Meningitis |
| 14. Influenza A Virus |
| May undergo antigenic shift and antigenic drift |
| May cause pandemics |
| Respond to rimantidine |
| Respond to neuraminidase inhibitors |
| Vaccination confers lifelong protection |
| 15. Paramyxoviruses may cause |
| Croup |
| Maculopapular rash |
| Pneumonia |
| Bronchiolitis |
| Diarrhoea |
| 16. Respiratory Syncytial Virus (RSV) |
| Respond to Amantidine |
| May cause bronchiolitis |
| May cause croup |
| May cause pneumonia |
| May be prevented by vaccination |
| 17. Parvoviruses |
| Causes Roseola Infantum |
| Causes Erythema Infectiousum |
| Is teratogenic |
| May cause abortion |
| May cause aplastic crisis in persons with haemolytic anaemias |
| Causes a vesicular rash |
| May cause encephalitis |
| May respond to acyclovir |
| May be prevented by HNIG |
| May be prevented by vaccination |
| 19. Rubella Virus |
| The rash of rubella is similar to that caused by parvo and enteroviruses |
| Is teratogenic |
| Congenital rubella is charaterised by eye, ear and heart defects |
| Congenital rubella is diagnosed by the finding of rubella-specific antibody in the cord blood of infants |
| Infants with congenital rubella poses a great infectious risk. |
| 20. Human T-lymphotropic virus 1 (HTLV-1) is associated with |
| Burkitt's lymphoma |
| Adult T-cell lymphoma |
| Tropical Spastic Paraparesis |
| Multiple Sclerosis |
| Hodgkin's lymphoma |
| 21. HIV Infection may lead to |
| Dementia |
| Chronic Diarrhoea |
| CMV retinitis |
| Oesophageal candidiasis |
| Non-Hodgkin's lymphoma |
| HIV envelope antibody |
| HIV-p24 antigen |
| CD4 count |
| HIV pro-viral DNA in leucocytes |
| HIV plasma RNA |
| 23. A chronic carrier state may occur in the following: |
| Hantavirus Infection |
| Hepatitis A |
| Hepatitis B |
| Hepatitis C |
| Smallpox Infection |
| HbeAg |
| Anti-HBc IgG |
| Anti-HBc IgM |
| HBV-DNA |
| HbsAg |
| 25. The following statements are true |
| Chronic HBV infection may respond to interferon therapy |
| Chronic HCV infection may respond to interferon therapy |
| Chronic HCV infection may respond to ribavirin therapy |
| Hepatitis Delta infection may be prevented by vaccination against HBV |
| Hepatitis E Infection may be prevented by vaccination |
| 26. The following viruses can be transmitted by blood |
| Hepatitis A |
| HIV |
| HTLV-1 |
| HBV |
| HCV |
| 27. Regarding viral infection of the central nervous system (CNS) |
| Meningitis may occur together with encephalitis |
| Enteroviruses are one of the commonest causes of CNS infections in childhood |
| HSV encephalitis is a postinfectious encephalomyelitis |
| Measles encephalitis is a postinfectious encephalomyelitis |
| The detection of antibody in the CSF is a useful diagnostic marker |
| 28. The following viruses are associated with gastroenteritis |
| Astroviruses |
| Norwalk-like viruses |
| Caliviruses |
| Adenoviruses |
| Rotaviruses |
| 29. The following viruses are transmitted from animals to humans |
| Rabies Virus |
| Polioviruses |
| CMV |
| Hantaviruses |
| Lassa Fever Virus |
| 30. The following is true of rabies virus |
| The majority of cases worldwide result from bat bites |
| Infection may be prevented by active and passive immunisation |
| Rabies vaccine is a live attenuated vaccine |
| The animal reservoir differ from country to country |
| May be diagnosed by serology |
