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Multiple Choice Questions - Paper 1

 

Instructions for candidates

The examination consists of 30 multiple choice questions, each divided into 5 different parts. Each part contains a statement which could be true or false. Each question will have at least one part which is true. For each part, you should indicate whether you think it is true (T), false (F), or don’t know (DN). You must fill in the relevant square with a black pen. One mark will be given for each correct answer and one mark deducted for each incorrect answer. You will not be marked for those questions for which you have indicated "don’t know".
 

1. Viruses
Contain both DNA and RNA
May have an envelope
Have their own metabolism
May contain enzymes for replication
Cell wall
 
2. The following are DNA viruses
Herpesviruses
Orthomyxoviruses
Enteroviruses
Hepadnaviruses
Parvoviruses
 
3. The following are RNA viruses
Picornaviruses
Adenoviruses
Papillomaviruses
Rhabdoviruses
Rotaviruses
 
4. Live attenuated vaccines are available against the following viruses
Influenza A Virus
Hepatitis B Virus
Rubella Virus
Yellow Fever Virus 
Varicella-Zoster Virus
 
5. The following antiviral agents is active against the following virus
Lamivudine and HIV
Lamivudine and HBV
Amantidine and Influenza B virus
Ribavirin and RSV
Acyclovir and HSV
 


 
 
 
 

6. Herpes Simplex Encephalitis
Commonly affect the temporal lobe
Is usually diagnosed by culture of the CSF
May be diagnosed by PCR of the CSF
Should be treated with IV ganciclovir
May be diagnosed by the finding of specific antibody in the CSF
 
  • 7. The following statements are true of Varicella-Zoster Virus
  •  
    Causes a maculopapular rash
    Respond to AZT therapy
    Remains latent in sensory ganglia following primary infection
    Recurrent episodes of Shingles usually occur
    Patients with shingles are not infectious
     
    8. Cytomegalovirus (CMV)
    Primary infection is usually symptomatic
    An infectious mononucleosis-like syndrome may occur during primary infection.
    May cause severe infection in immunocompromised individuals
    Is teratogenic
    Causes Kawasaki's Disease
     
    9. Epstein-Barr Virus (EBV) is associated with
    Infectious Mononucleosis
    Hepatitis
    Burkitt's lymphoma
    Nasopharyngeal carcinoma
    Oral leukoplakia 
     
  • 10. HHV-6 is associated with
  • Fifth disease
    Roseala Infantum
    Kaposi's Sarcoma
    Infectious Mononucleosis-like illness
    Oral leukoplakia


     
     

  • 11. Adenoviruses
  • Are associated with genital cancers
    May cause gastroenteritis
    May cause conjunctivitis
    May cause pneumonia
    May cause warts
     
    12. Papillomaviruses
    HPV-6 and HPV-11 are associated with genital cancers
    HPV-16 and HPV-18 are associated with genital cancers
    Warts caused by papillomaviruses may respond to interferon therapy
    Papillomavirus infection is commonly diagnosed by viral culture
    Are associated with progressive multifocal leucoencephalopathy (PML)
     
    13. Coxsackie B Virus is associated with the following
     
    Paralytic illness
    Myocarditis
    Bornholm's disease
    Severe congenital infection
    Meningitis
     
    14. Influenza A Virus
    May undergo antigenic shift and antigenic drift
    May cause pandemics
    Respond to rimantidine
    Respond to neuraminidase inhibitors
    Vaccination confers lifelong protection
     
    15. Paramyxoviruses may cause
    Croup
    Maculopapular rash
    Pneumonia
    Bronchiolitis
    Diarrhoea
     


     
     

    16. Respiratory Syncytial Virus (RSV)
    Respond to Amantidine
    May cause bronchiolitis 
    May cause croup
    May cause pneumonia
    May be prevented by vaccination
     
    17. Parvoviruses
    Causes Roseola Infantum
    Causes Erythema Infectiousum
    Is teratogenic
    May cause abortion
    May cause aplastic crisis in persons with haemolytic anaemias
     
  • 18. Measles Virus Infection
  • Causes a vesicular rash
    May cause encephalitis
    May respond to acyclovir
    May be prevented by HNIG
    May be prevented by vaccination
     
    19. Rubella Virus
    The rash of rubella is similar to that caused by parvo and enteroviruses
    Is teratogenic
    Congenital rubella is charaterised by eye, ear and heart defects
    Congenital rubella is diagnosed by the finding of rubella-specific antibody in the cord blood of infants
    Infants with congenital rubella poses a great infectious risk.
     
    20. Human T-lymphotropic virus 1 (HTLV-1) is associated with
    Burkitt's lymphoma
    Adult T-cell lymphoma
    Tropical Spastic Paraparesis
    Multiple Sclerosis
    Hodgkin's lymphoma
     


     
     

    21. HIV Infection may lead to
    Dementia
    Chronic Diarrhoea
    CMV retinitis
    Oesophageal candidiasis
    Non-Hodgkin's lymphoma
     
  • 22. The following may be useful for prognostic purposes in HIV-infected individuals 
  • HIV envelope antibody
    HIV-p24 antigen
    CD4 count
    HIV pro-viral DNA in leucocytes
    HIV plasma RNA
     
    23. A chronic carrier state may occur in the following:
    Hantavirus Infection
    Hepatitis A
    Hepatitis B
    Hepatitis C
    Smallpox Infection
     
  • 24. The following markers are usually present in a hepatitis B carrier with chronic active hepatitis
  • HbeAg
    Anti-HBc IgG
    Anti-HBc IgM
    HBV-DNA
    HbsAg
     
    25. The following statements are true
    Chronic HBV infection may respond to interferon therapy
    Chronic HCV infection may respond to interferon therapy
    Chronic HCV infection may respond to ribavirin therapy
    Hepatitis Delta infection may be prevented by vaccination against HBV
    Hepatitis E Infection may be prevented by vaccination


     
     

    26. The following viruses can be transmitted by blood
    Hepatitis A
    HIV
    HTLV-1
    HBV
    HCV
     
    27. Regarding viral infection of the central nervous system (CNS)
    Meningitis may occur together with encephalitis
    Enteroviruses are one of the commonest causes of CNS infections in childhood
    HSV encephalitis is a postinfectious encephalomyelitis
    Measles encephalitis is a postinfectious encephalomyelitis
    The detection of antibody in the CSF is a useful diagnostic marker
     
    28. The following viruses are associated with gastroenteritis
    Astroviruses
    Norwalk-like viruses
    Caliviruses
    Adenoviruses
    Rotaviruses
     
    29. The following viruses are transmitted from animals to humans
    Rabies Virus
    Polioviruses
    CMV
    Hantaviruses
    Lassa Fever Virus
     
    30. The following is true of rabies virus
    The majority of cases worldwide result from bat bites
    Infection may be prevented by active and passive immunisation
    Rabies vaccine is a live attenuated vaccine
    The animal reservoir differ from country to country
    May be diagnosed by serology

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