Multiple Choice Questions - Paper 3
Instructions for candidates
The examination consists of 30 multiple choice questions, each
divided into 5 different parts. Each part contains a statement
which could be true or false. Each question will have at least
one part which is true. For each part, you should indicate
whether you think it is true (T), false (F), or don’t know (DN).
You must fill in the relevant square with a black pen. One mark
will be given for each correct answer and one mark deducted for
each incorrect answer. You will not be marked for those questions
for which you have indicated "don’t know".
| 1. The following are DNA viruses |
| Influenza A virus |
| Rubella Virus |
| Hepatitis B Virus |
| CMV Virus |
| Parvovirus |
| 2. The following are negatively stranded RNA viruses |
| Picornaviruses |
| Orthomyxoviruses |
| Coronaviruses |
| Flaviviruses |
| Rhabdoviruses |
| 3. The following viruses have segmented genomes |
| Orthomyxoviruses |
| Herpesviruses |
| Paramyxoviruses |
| Bunyaviruses |
| Rotaviruses |
| 4. The following are enveloped viruses |
| Herpesviruses |
| Adenoviruses |
| Rotaviruses |
| Parvoviruses |
| Orthomyxoviruses |
| 5. All viruses |
| Contain DNA |
| Contain RNA |
| Contain protein |
| Are susceptible to lipid solvents |
| Are intracellular parasites |
| 6. The following viruses are associated with human cancers |
| HSV-2 |
| EBV |
| HCV |
| Adenoviruses |
| HHV-8 |
| HSV-2 |
| Rubella |
| HIV |
| HBV |
| CMV |
| 8. The following viruses have reverse transcriptase |
| HIV |
| Parovirus |
| HBV |
| CMV |
| HTLV-1 |
| 9. The following viruses replicate in the nucleus |
| Herpseviruses |
| Poxviruses |
| Picornaviruses |
| Orthomyxoviruses |
| Paramyxoviruses |
| Rubella |
| Rabies |
| Hantaviruses |
| Lassa Fever |
| Japanese Encephalitis |
| HSV-1 |
| HBV |
| HIV |
| Influenza A Virus |
| Rotaviruses |
| 12. The following statements are true of prions |
| Readily inactivated by autoclave at 121oC |
| Contain DNA |
| Have long incubation periods |
| Highly immunogenic |
| May be readily cultured |
| 13. The following are "slow virus" diseases |
| Herpes Simplex Encephalitis |
| Creutzfeldt-Jacob disease |
| Subacute Scelerosing Panecephalitis (SSPE) |
| Rabies |
| Progressive multifocal leucoencephalopathy (PML) |
| 14. HSV-1 infection may result in |
| Encephalitis |
| Gingivostomatitis |
| Genital Herpes |
| Corneal Ulcers |
| Shingles |
| 15. The following viruses are associated with a vesicular rash |
| Rubella Virus |
| Measles Virus |
| Parvovirus |
| HSV-1 |
| VZV |
| 16. Cytomegalovirus (CMV) |
| Primary infection is usually asymptomatic |
| An infectious mononucleosis-like syndrome may occur during primary infection. |
| May cause severe infection in immunocompromised individuals |
| May cause congenital infection |
| Reactivate from time to time |
| 17. Epstein-Barr Virus (EBV) is associated with |
| Infectious Mononucleosis |
| Kaposi's Sarcoma |
| Burkitt's lymphoma |
| Nasopharyngeal carcinoma |
| Adult T-cell lymphoma |
| Fifth disease |
| Roseala Infantum |
| Kaposi's Sarcoma |
| Nasopharyngeal Carcinoma |
| Oral leukoplakia |
| 19. The following viruses are thought to cause gastroenteritis |
| Enteroviruses |
| Caliciviruses |
| Norwalk-like viruses |
| Astroviruses |
| Paramyxoviruses |
| 20. The following statements are true |
| Human polyoma virus JC is associated with progressive multifocal leucoencephalopathy (PML) |
| Human polyoma virus JC is associated with warts |
| HPV-6 and HPV-11 are associated with genital cancers |
| HPV-6 and HPV-11 are associated with Juvenile laryngeal papillomatosis |
| Patients with Epidermodysplasia verruciformis are susceptible to widespread warts caused by HPV |
| 21. The following statements are true |
| Influenza A may undergo antigenic shift |
| Influenza B may undergo antigenic shift |
| Influenza A may undergo antigenic drift |
| Influenza B may undergo antigenic drift |
| Influenza B may respond to amantidine |
| 22. Respiratory Syncytial Virus |
| Cause disease mainly in adults |
| May cause bronchiolitis |
| May be prevented by vaccination |
| May be treated by amantidine |
| May cause latent infections |
| 23. HIV may respond to |
| Nucleoside analogues |
| Protease inhibitors |
| Neuraminidase inhibitors |
| Reverse transcriptase inhibitors |
| Acyclovir |
| 24. During the incubation period of HIV infection, there is |
| Little HIV replication |
| HIV is mainly integrated into the genome of long-lived cell populations |
| High turnover of CD4 cells |
| The viral load has a direct bearing on the prognosis |
| Little antibody against the HIV envelope |
| 25. Hepatitis A infection |
| May result in chronic infection |
| May be prevented by immunoglobulin |
| May be prevented by vaccination |
| Is highly infectious during the jaundice phase |
| May result in cirrhosis |
| May result in chronic infection |
| May result in cirrhosis of the liver |
| May result in hepatocellular carcinoma |
| Is highly infectious when positive for anti-HbeAg antibody |
| May respond to interferon therapy |
| 27. The following statements are true of hepatitis B core escape mutants |
| Associated with fulminant hepatitis |
| HbeAg positive |
| HbeAg positive |
| HBV-DNA positive |
| Anti-HbsAg antibody positive |
| 28. Hepatitis C virus |
| May be transmitted by blood |
| Is associated with hepatocellular carcinoma |
| May respond to interferon therapy |
| Has one stable genotype only |
| May cause chronic infection |
| 29. The following statements are true |
| Dengue virus infection result from bites by Aedes mosquitoes |
| Cases of dengue haemorrhagic fever usually result from reinfection by a different serotype of dengue virus |
| Pigs act as the reservoir for dengue virus |
| Yellow fever is prevalent throughout Asia |
| Yellow fever may be prevented by vaccination |
| 30. Measles virus |
| Infection may result in pneumonia |
| Infection may result in encephalitis |
| Undergo antigenic drift |
| May respond to acyclovir |
| May be prevented by vaccination |
