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Multiple Choice Questions - Paper 3

 

Instructions for candidates

The examination consists of 30 multiple choice questions, each divided into 5 different parts. Each part contains a statement which could be true or false. Each question will have at least one part which is true. For each part, you should indicate whether you think it is true (T), false (F), or don’t know (DN). You must fill in the relevant square with a black pen. One mark will be given for each correct answer and one mark deducted for each incorrect answer. You will not be marked for those questions for which you have indicated "don’t know".
 

1. The following are DNA viruses
Influenza A virus
Rubella Virus
Hepatitis B Virus
CMV Virus
Parvovirus
 
2. The following are negatively stranded RNA viruses
Picornaviruses
Orthomyxoviruses
Coronaviruses
Flaviviruses
Rhabdoviruses
 
3. The following viruses have segmented genomes
Orthomyxoviruses
Herpesviruses
Paramyxoviruses
Bunyaviruses
Rotaviruses
 
4. The following are enveloped viruses
Herpesviruses
Adenoviruses
Rotaviruses
Parvoviruses
Orthomyxoviruses
 
5. All viruses
Contain DNA
Contain RNA
Contain protein
Are susceptible to lipid solvents
Are intracellular parasites


 
 
 
 

6. The following viruses are associated with human cancers
HSV-2
EBV
HCV
Adenoviruses
HHV-8
 
  • 7. The following viruses may cause congenital infection
  •  HSV-2
    Rubella
    HIV
    HBV
    CMV
     
     
    8. The following viruses have reverse transcriptase
    HIV
    Parovirus
    HBV
    CMV
    HTLV-1
     
    9. The following viruses replicate in the nucleus
    Herpseviruses
    Poxviruses
    Picornaviruses
    Orthomyxoviruses
    Paramyxoviruses
     
  • 10. The following are viral zoonoses
  • Rubella
    Rabies
    Hantaviruses
    Lassa Fever
    Japanese Encephalitis


     
     
     
     

  • 11. Reassortment of genes may occur with
  • HSV-1
    HBV
    HIV
    Influenza A Virus
    Rotaviruses
     
    12. The following statements are true of prions
    Readily inactivated by autoclave at 121oC
    Contain DNA
    Have long incubation periods
    Highly immunogenic
    May be readily cultured
     
    13. The following are "slow virus" diseases
    Herpes Simplex Encephalitis
    Creutzfeldt-Jacob disease
    Subacute Scelerosing Panecephalitis (SSPE)
    Rabies
    Progressive multifocal leucoencephalopathy (PML)
     
    14. HSV-1 infection may result in
    Encephalitis
    Gingivostomatitis
    Genital Herpes
    Corneal Ulcers
    Shingles
     
    15. The following viruses are associated with a vesicular rash
    Rubella Virus
    Measles Virus
    Parvovirus 
    HSV-1
    VZV
     


     
     
     
     

    16. Cytomegalovirus (CMV)
    Primary infection is usually asymptomatic
    An infectious mononucleosis-like syndrome may occur during primary infection.
    May cause severe infection in immunocompromised individuals
    May cause congenital infection
    Reactivate from time to time
     
    17. Epstein-Barr Virus (EBV) is associated with
    Infectious Mononucleosis
    Kaposi's Sarcoma
    Burkitt's lymphoma
    Nasopharyngeal carcinoma
    Adult T-cell lymphoma
     
  • 18. HHV-8 is associated with
  • Fifth disease
    Roseala Infantum
    Kaposi's Sarcoma
    Nasopharyngeal Carcinoma
    Oral leukoplakia
     
    19. The following viruses are thought to cause gastroenteritis 
    Enteroviruses
    Caliciviruses
    Norwalk-like viruses
    Astroviruses
    Paramyxoviruses
     
    20. The following statements are true
    Human polyoma virus JC is associated with progressive multifocal leucoencephalopathy (PML)
    Human polyoma virus JC is associated with warts
    HPV-6 and HPV-11 are associated with genital cancers
    HPV-6 and HPV-11 are associated with Juvenile laryngeal papillomatosis
    Patients with Epidermodysplasia verruciformis are susceptible to widespread warts caused by HPV
     


     
     
     
     

    21. The following statements are true
    Influenza A may undergo antigenic shift
    Influenza B may undergo antigenic shift
    Influenza A may undergo antigenic drift
    Influenza B may undergo antigenic drift
    Influenza B may respond to amantidine
     
    22. Respiratory Syncytial Virus
    Cause disease mainly in adults
    May cause bronchiolitis
    May be prevented by vaccination
     May be treated by amantidine
     May cause latent infections
     
     23. HIV may respond to 
     Nucleoside analogues
     Protease inhibitors
     Neuraminidase inhibitors
     Reverse transcriptase inhibitors
     Acyclovir
     
     24. During the incubation period of HIV infection, there is
     Little HIV replication
     HIV is mainly integrated into the genome of long-lived cell populations
     High turnover of CD4 cells
     The viral load has a direct bearing on the prognosis
     Little antibody against the HIV envelope
     
     25. Hepatitis A infection
     May result in chronic infection
     May be prevented by immunoglobulin
     May be prevented by vaccination
     Is highly infectious during the jaundice phase
     May result in cirrhosis


     
     
     
     

  • 26. Hepatitis B infection
  • May result in chronic infection
    May result in cirrhosis of the liver
    May result in hepatocellular carcinoma
    Is highly infectious when positive for anti-HbeAg antibody
    May respond to interferon therapy
     
    27. The following statements are true of hepatitis B core escape mutants
    Associated with fulminant hepatitis
    HbeAg positive
    HbeAg positive
    HBV-DNA positive
    Anti-HbsAg antibody positive
     
    28. Hepatitis C virus
    May be transmitted by blood
    Is associated with hepatocellular carcinoma
    May respond to interferon therapy
    Has one stable genotype only
    May cause chronic infection
     
    29. The following statements are true
    Dengue virus infection result from bites by Aedes mosquitoes
    Cases of dengue haemorrhagic fever usually result from reinfection by a different serotype of dengue virus
    Pigs act as the reservoir for dengue virus
    Yellow fever is prevalent throughout Asia
    Yellow fever may be prevented by vaccination
     
    30. Measles virus 
    Infection may result in pneumonia
    Infection may result in encephalitis
    Undergo antigenic drift
    May respond to acyclovir
    May be prevented by vaccination

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