Other Poxviruses Infection
Monkeypox was first isolated from monkeys in 1958, but it was not until 1970 that it was associated with human disease. To date, over 400 cases have been investigated, mainly from Zaire. The pathogenesis and clinical features for monkeypox is the same as for smallpox. The main differences are a greater degree of lymphadenopathy and a lower capacity for case-to-case spread. Most cases occur in unvaccinated children. The mortality in human monkeypox is appreciable, being in the order of 10%. The management of human monkeypox is the same as for smallpox. Human monkeypox has not been detected outside West Africa. Although monkeypox was first isolated from monkeys, there is no evidence that African monkeys act as the reservoir. The most likely candidate for reservoir is the African squirrel. One important difference between human monkeypox and smallpox is the lower capacity for human spread. The attack rate among unvaccinated contacts is 9% in contrast to >37% for smallpox. Laboratory workers studying monkeypox should be vaccinated.
Vaccination with vaccinia was associated with certain risks. Complications ranged from mild reactions and fatal encephalitis. The overall incidence of complications was around 1/800 although the more severe forms occurred only in 15 per million vaccinees. Recent interest has focused on the possible usage of vaccinia as a vector for immunization against other viruses. It is possible that certain changes can be made to the vaccinia genome which makes it less likely to develop side effects.
Cowpox is a relatively unimportant zoonosis which has only been isolated in Britain and Europe. Infection has been described in humans, cows and cats. Infection in humans usually remain localized, often producing a lesion which is similar to that caused by vaccination, although the inflammatory response is greater and general constitutional symptoms such as fever and myalgia may be present in some cases. In humans, lesions are usually restricted to the hands, but may also be transferred to the face. EM is generally used for the diagnosis of infection. The virus will also grow well on CAM. Human cowpox usually respond to treatment with antivaccinia immunoglobulin, but its use should be restricted to the most severe cases. Although cowpox was first isolated form cattle and farm workers. There is no evidence that cattle serve as the reservoir. In fact, cowpox is very rare in cattle. It has been suggested that the reservoir is actually a small rodent but this is not proven.
Parapoxvirus infections are widespread in sheep, goats and cattle and relatively unimportant but common human infections occur. Infections in cattle and humans are usually referred to as pseudocowpox, paravaccinia or milker's nodes. Those in sheep and goats as orf. The viruses are closely related and the nomenclature of the human disease is based on the identity of the host form which the infection was acquired. (orf from sheep and pseudocowpox from cattle). Infection occurs via small cuts and abrasions in all hosts and is usually localized. Although the lesions are similar to the early lesions of cowpox and vaccinia, true macrovesicles do not form. In humans, lesions usually occur on the hand but may be transferred to the face. The laboratory diagnosis is usually made by EM. The virus may also be isolated in human, bovine and ovine cells but such investigations are not part of routine diagnostic virology. Parapoxvirus infections occur worldwide, and are of considerable importance. A survey carried in New Zealand showed that 1.4% of workers in the meat industry became infected in 1 year. The lesions are surprisingly painless and thus there is probably substantial under-reporting. Idoxuridine had occasionally been prescribed for treatment but no trials have been carried out to prove the efficacy of treatment. Prevention of human infection is difficult. Reasonable precautions should be undertaken when handling infected animals.
5. Molluscum Contagiosum
Molluscum contagiosum is a specifically human disease of worldwide distribution. The incubation period varies from 1 week to 6 months. The lesion begins as a small papule and gradually grows into a discrete, waxy, smooth, dome-shaped, pearly or flesh-coloured nodule. Usually 1-20 lesions but occasionally they may be present in hundreds. In children, the lesions are found on the trunk and the proximal extremities. In adults they tend to occur on the trunk, pubic area and thighs. Individual lesions persist for about 2 months, but the disease usually lasts 6 to 9 months. Constitutional disturbance is rare. The disease occurs world-wide and is spread by direct contact or fomites. In general it tends to occur in children. The disease by may transmitted from skin to skin after sexual intercourse. A diagnosis can usually be made on clinical appearance alone. The diagnosis can be supported by EM. Unlike other poxviruses, molluscum have not been demonstrated to grow in cell culture. Infection is usually benign and painless, with spontaneous recovery in most cases. Where treatment is required for cosmetic reasons, various procedures are available such as curretage, cryotherapy with liquid nitrogen, silver nitrate etc. which are routinely used for the removal of warts.
Tanapox is a poxvirus infection first recognized in 1957 in the Tana River area of Kenya. It is a zoonosis, human cases have only been seen in the Tana valley and Zaire. The distribution of the virus and the real extent of the human infection is not known, as is the method of transmission of infection. The virus produces a mild febrile illness with one or two skin lesions. The virus does not grow in CAM but will grow in a variety of cell lines.